MOTS-c: Research Peptide, Molecular Properties, and Scientific Applications

What Is MOTS-c (HUMAN)?

MOTS-c(HUMAN) is a 16-amino-acid mitochondrial-derived peptide that has become an important subject of research in molecular biology, metabolism, mitochondrial signaling, and aging-related science.

The name MOTS-c stands for mitochondrial open reading frame of the 12S rRNA-c. Unlike many well-known peptides that are encoded by nuclear genes, MOTS-c originates from a short open reading frame within the mitochondrial genome’s 12S ribosomal RNA region. It was first described in 2015 as a previously unidentified mitochondrial-derived signaling peptide.

The human MOTS-c sequence is:

MRWQEMGYIFYPRKLR

This sequence contains 16 amino acids and is highly conserved in its N-terminal region across several species, including humans and mice.

MOTS-c has attracted scientific interest because studies suggest that it may participate in cellular responses involving metabolic homeostasis, energy regulation, stress responses, mitochondrial biology, and AMPK-related signaling.

Importantly, much of the research surrounding MOTS-c remains preclinical. Findings from cell and animal models should not be interpreted as proof that MOTS-c is an established treatment for metabolic disease, obesity, aging, or other human conditions.

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MOTS-c (HUMAN) at a Glance

Property	Information
Product name	MOTS-c (HUMAN)
Full name	Mitochondrial Open Reading Frame of the 12S rRNA-c
Peptide type	Mitochondrial-derived peptide
Length	16 amino acids
Human sequence	MRWQEMGYIFYPRKLR
Genetic origin	Mitochondrial 12S rRNA region
Research areas	Metabolism, mitochondrial biology, aging, cellular signaling
Key pathway investigated	AMPK and metabolic signaling
Research status	Primarily preclinical
Intended context	Laboratory and scientific research

The original discovery paper described MOTS-c as a 16-amino-acid peptide encoded by a short open reading frame within mitochondrial 12S rRNA.

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MOTS-c (HUMAN) Peptide Sequence

The reported human MOTS-c sequence is:

MRWQEMGYIFYPRKLR

Breaking this sequence down:

M – Methionine
R – Arginine
W – Tryptophan
Q – Glutamine
E – Glutamic acid
M – Methionine
G – Glycine
Y – Tyrosine
I – Isoleucine
F – Phenylalanine
Y – Tyrosine
P – Proline
R – Arginine
K – Lysine
L – Leucine
R – Arginine

The 16-residue sequence is identified in the scientific literature as the human MOTS-c peptide.

The sequence is particularly relevant to research because MOTS-c represents a class of signaling peptides encoded by mitochondrial short open reading frames.

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